Corporate Officers
David A. Zippin, M.B.A., J.D. President & Chief Executive Officer
Our Expert Scientific Advisors
Jochen Buck, M.D., PhD
Dr. Buck has been studying intracellular cAMP signaling pathways for the last
14 years. He received his MD and PhD from the University of Tubingen (Germany).
As a Post-doctoral Fellow in the laboratory of Dr. Ulrich Hammerling at
Sloan-Kettering Cancer Center, he studied intracellular signaling by vitamin A,
and he continued these studies during his first years as a faculty member of
the Pharmacology Department of Weill Cornell Medical College. Starting in 1998,
he collaborated with Dr. Lonny Levin to identify, clone, and biochemically
characterize a novel form of adenylyl cyclase in mammals, the soluble adenylyl cyclase
(sAC). He and Dr. Levin remain collaborators studying the biochemistry and
biology of mammalian sAC. They have combined their laboratories into a joint
research program studying bicarbonate/carbon dioxide chemosensing via the
second messenger cAMP.
Chen*, Y.,
M.J. Cann*, T.N. Litvin, V. Iourgenko, M.L. Sinclair, L.R. Levin, and J. Buck
(2000). Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate
sensor. Science 289: 625-628. PMID: 10915626
Hess, K.C.*,
Jones, B.H.*, Marquez, B., Chen, Y., Ord, T.S., Kamenetsky, M., Myamoto, C.,
Zippin, J.H., Kopf, G.S., Suarez, S.S., Levin, L.R.*, Williams, C.J.*, Buck,
J.*, & Moss, S.B.* (2005). The “soluble” adenylyl cyclase in sperm mediates
multiple signaling events required for fertiliztion. Dev. Cell 9: 249-259.
PMID: 16054031
Tresguerres, M., Levin, L.R., and Buck, J. (2011) Intracellular cAMP
signaling by soluble adenylyl cyclase. Kidney Int. 79: 1277-1288.
Lonny Levin, PhD
Dr. Levin has been studying the cAMP signaling pathway for over 20 years and
adenylyl cyclases for over 15. As a Graduate Student in the Laboratory of Dr.
Mark J. Zoller at Cold Spring Harbor Laboratory, he used molecular genetics and
biochemistry to study the regulation of Protein Kinase A, the predominant cAMP
effector protein in cells. As a Post-doctoral Fellow in the laboratory of Dr.
Randall R. Reed at Johns Hopkins School of Medicine, he cloned and
characterized the first Drosophila adenylyl cyclase. As a member of the
Pharmacology Department of Weill Cornell Medical College, he first continued
his studies identifying and characterizing Drosophila adenylyl cyclase genes.
Then in 1998, he collaborated with Dr. Buck to identify, clone, and
biochemically characterize a novel form of adenylyl cyclase in mammals, the
soluble adenylyl cyclase (sAC). He and Dr. Buck remain collaborators studying
the biochemistry and biology of mammalian sAC. They have combined their
laboratories into a combined research program studying bicarbonate/carbon
dioxide chemosensing via the second messenger cAMP.
Buck*,
J., M.L. Sinclair*, L. Schapal, M.J. Cann, and L.R. Levin (1999). Cytosolic
adenylyl cyclase defines a unique signaling molecule in mammals. Proc. Natl.
Acad. Sci. 96:79-84. PMID: 9874775
Tresguerres,
M. Buck, J. and Levin, L.R. (2010). Physiological carbon dioxide, bicarbonate
and pH sensing. Pflugers Archiv - European Journal of Physiology 460:953-964.
PMID: 20683624
Lee,
Y-S., Tresguerres, M., Hess, K., Marmorstein, L.Y., Levin, L.R., Buck, J., and
Marmorstein, A.D. (2011). Regulation of anterior chamber drainage by
bicarbonate sensitive adenylyl cyclase in the ciliary body. J. Biol. Chem:jbc.M111.284679.
doi:10.1074/jbc.M111.284679. PMID: 21994938
Jonathan H. Zippin, M.D., PhD
Jonathan Hale Zippin M.D., Ph.D. is an Attending Dermatologist and Instructor
in Dermatology at Weill Medical College of Cornell. Dr. Zippin attended Cornell
University where he received a Bachelor of Science with Honors. He then
attended the Rockefeller/Cornell/Sloan-Kettering Tri-Institutional
MD/PhD
program. He then completed his general medicine internship at the Mount
Sinai
Hospital in New York City, followed by a residency in dermatology at the
Weill
Cornell Medical Center - New York Presbyterian Hospital. Dr. Zippin is a
member of the American Academy of Dermatology, the American
Society of Dermatologic Surgery, and the American Contact Dermatitis
Society.
He is also a member of the medical editorial board of the Journal of
Drugs in
Dermatology. Dr. Zippin is the author of numerous peer-reviewed
publications in the area of
signal transduction and skin disease, and has published a variety of
papers
reviewing the treatment of dermatologic diseases.
Cynthia Magro, M.D.
Dr. Cynthia Magro is professor of
pathology and laboratory medicine and director of the comprehensive dermatopathology service at the Weill College of Medicine of Cornell
University located in upper east side of Manhattan. Dr. Magro
received her training at Harvard Medical School. She is internationally known
in dermatopathology, having co-authored over 200 papers, several book chapters,
and three textbooks: the Melanocytic Proliferation, the Cutaneous Lymphoid
proliferation, and Cutaneous Biopsy Interpretation. She is a co-editor on the
Barnhill Textbook of Dermatopathology. Her expertise has focused on the
pathologic assessment of cutaneous autoimmune disease, viral disease,
immunofluorescence, drug reactions, benign, atypical an neoplastic lymphocytic
infiltrates of the skin, and problematic melanocytic proliferations. In addition
she has expertise in the area of non-neoplastic lung disease where she has
functioned as the senior author on several papers in the areas of pulmonary
vasculitis, idiopathic pulmonary fibrosis and lung transplantation. She has
also developed a novel approach to the evaluation of non-neoplastic
inflammatory lung disease via direct immunofluorescent techniques, which has
been published in the new 2008 book Pulmonary Pathology (Churchill Liningstone).
She currently runs the non-neoplastic lung service at the Weill College of Medicine
and New York Hospital. Dr. Cynthia Magro has been recognized as a New York Times,
Super Doctor in 2008, 2009, and 2010. She has also been listed in the Castle Connolly Medical Limited as a Top Doctor for the New
York Metro Area in 2010 and 2011. She is a
member of the American Society of Dermatopathology and United States and
Canadian Academy of Pathologists.
|
|
|